NGS
The method, known as NGS or Next Generation Sequencing, is a chromosome screening technology found in Preimplantation Genetic Screening applications. A possible genetic problem in the embryos is identified using NGS, which is used prior to embryo transfer. The application’s most important feature is that healthy embryos can be selected using a genetic analysis performed before the pregnancy period begins. The NGS method, which scans all 24 chromosomes, allows for the identification of potential translocations as well as changes in chromosome count.
To Which Patients Can NGS Be Applied?
Generally, NGS method is preferred in the following cases:
•Failed IVF applications,
• Pregnancies over age of 38,
• Multiple pregnancy losses,
• Karyotype changes depending on the individual, which are called as translocation
How Is NGS Application Performed?
NGS is a genetic analysis performed on embryos created by the fertilization of sperm and egg samples obtained from spouses. Previously, blastomere biopsy analysis could be performed on 3rd day embryos; however, trophectoderm biopsy can now be performed on the 5th or 6th day. As a result, the risk of a structural chromosome anomaly, known as mosaicism, can be reduced.
