What is Recurrent Failed IVF?
IVF treatment is one of the most effective assisted reproductive methods offered by modern medicine. However, in some cases, pregnancy may not occur despite several attempts.
Recurrent IVF failure is the condition in which pregnancy does not occur or results in miscarriage despite embryo transfer in two or more IVF attempts.
This situation can create significant psychological distress in couples. The FertiJin Women’s Health and IVF Center in Şişli, Istanbul aims to increase success rates by identifying the underlying causes of recurrent failures and creating personalized treatment plans.
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Why Does IVF Treatment Fail?
There may be many reasons for IVF treatment failure. These may be related to both female and male factors, and sometimes no medical explanation may be found.
1. Embryo Quality
Embryo quality is the most important determinant of pregnancy success.
- Embryos with genetic abnormalities cannot implant in the uterus.
- Problems in egg or sperm quality may negatively affect embryo development.
In FertiJin laboratories, embryos are evaluated in detail with advanced technologies such as Embryoscope (EmbryoScope) and PGT (Preimplantation Genetic Testing).
2. Uterine (Uterus) Factors
Intrauterine adhesions, fibroids, polyps, or uterine shape abnormalities may prevent embryo implantation.
These conditions can be diagnosed and surgically treated with the hysteroscopy method.
3. Immune System and Hormonal Imbalances
In some women, the immune system may perceive the embryo as foreign tissue.
In this case, lymphocyte vaccine, intralipid serum therapy, or immune supportive protocols may be applied.
Additionally, thyroid, prolactin, and progesterone imbalances also negatively affect embryo implantation.
4. Male Factors
Low sperm count, insufficient motility, or genetic abnormalities may reduce fertilization quality.
At FertiJin, advanced micromanipulation techniques such as Micro TESE, ICSI are applied for male factors.
5. Lifestyle and Environmental Factors
Stress, smoking, alcohol, excess weight, poor nutrition, and sleep irregularities negatively affect IVF success. Lifestyle changes during the preparation period for treatment can significantly increase success rates.
Undetectable (Unexplained) Failures
In some cases, pregnancy cannot be achieved despite all tests being normal. In these cases:
- Immune system reactions,
- Disruption of intrauterine microflora,
- Sperm DNA damage,
- Embryo and endometrium incompatibility may play a role as microscopic factors.
At this point, advanced diagnostic methods (ERA test, DNA fragmentation analysis, etc.) are utilized.
What Should Be Done After Failed IVF Attempts?
The failure of IVF attempts does not mean that the next treatment will also fail.
The most important factor is correctly identifying the cause and creating a personalized roadmap.
Practices That Increase Success at FertiJin:
- Advanced embryo selection (Embryoscope + PGT)
- Optimization of uterine preparation (Hormone and vitamin support)
- Immune system-specific treatments
- Nutrition, stress management, and psychological support programs
At FertiJin Women’s Health and IVF Center, each attempt is replanned with personalized analyses.
The goal is not only embryo transfer but also increasing healthy pregnancy and live birth rates.
Frequently Asked Questions
Why does IVF treatment not work?
The most common causes are low embryo quality, uterine problems, hormonal imbalance, and genetic abnormalities.
How many times can IVF be attempted?
There is no specific medical limit. However, in each attempt, the cause should be analyzed and a personalized protocol should be prepared.
How long should one wait after a failed IVF?
Generally, 1–2 months are allowed for the body to recover. However, this period may vary according to the doctor’s recommendation.