What Is Recurrent Miscarriage?
Recurrent miscarriage is the termination of two or more pregnancies before the 20th week. Pregnancy losses before 20 weeks or fetal losses weighing less than 500 grams fall into this group.
- Losses experienced before 12 weeks are called early miscarriage,
- Those experienced between 12–20 weeks are called late miscarriage.
This condition is seen in approximately 1% of couples today and is one of the most common problems encountered in cases of unexplained infertility.
📍 FertiJin Women’s Health and IVF Center in Şişli, Istanbul analyzes the causes of recurrent miscarriages and creates personalized treatment plans.
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What Are the Causes of Recurrent Miscarriages?
Many factors, both known and unexplained, may underlie recurrent miscarriages.
The following causes constitute a large proportion of miscarriage cases:
1. Genetic Factors
Even if there is no genetic problem in the mother or father, age-related decline in egg and sperm quality may lead to genetic abnormalities in the embryo.
This condition causes the fertilized embryo to fail to develop and leads to miscarriages in the early period.
These risks can be identified by performing embryo genetic analyses (karyotype and PGT) in FertiJin laboratories.
2. Uterine Anomalies
Congenital or acquired structural abnormalities of the uterus, adhesions, fibroids, and polyps also increase the risk of miscarriage.
Such anomalies can be detected by hysteroscopy and corrected surgically.
3. Clotting Disorders (Thrombophilia)
An imbalance of the enzymes that regulate blood clotting causes insufficient blood to reach the baby. This may result in miscarriage due to the embryo being deprived of oxygen.
4. Hormonal Imbalances
It is seen in approximately 10% of cases.
- Progesterone deficiency: The uterine lining cannot thicken sufficiently.
- High prolactin, thyroid disorders, diabetes, and insulin resistance: Prevent embryo implantation.
5. Immune System and Environmental Factors
The mother’s body perceiving the embryo as foreign tissue,
smoking, alcohol, stress, environmental toxins, and unhealthy lifestyle habits are also among the risk factors.
IVF Treatment in Recurrent Miscarriages
At FertiJin IVF Center, recurrent miscarriages are evaluated with comprehensive genetic and immunological tests before treatment planning.
Applied Methods:
1. PGT / PGD (Preimplantation Genetic Diagnosis)
Thanks to this method integrated into IVF treatment, embryos are genetically screened before transfer.
Only healthy embryos are transferred to the uterus, increasing pregnancy and live birth rates.
2. Corrective Uterine Surgeries
Intrauterine adhesions, septum, and fibroids are removed by hysteroscopy or laparoscopy.
3. Immune and Clotting Treatments
When necessary, lymphocyte vaccine, intralipid serum therapy, or blood-thinning medications are administered.
4. Hormone Regulation Treatments
The uterine lining is prepared for pregnancy with progesterone and thyroid hormone support.
FertiJin IVF Center achieves high success rates in recurrent miscarriages with personalized IVF protocols and genetics-supported approaches in Şişli, Istanbul.
Pregnancy After Recurrent Miscarriage
Attempting pregnancy before the uterus and hormonal balance are restored after a miscarriage is risky.
Generally, waiting at least 3 months is recommended.
During this period, adopting healthy lifestyle habits, stress management, and nutritional monitoring are of great importance.
Women under 35 may try for natural pregnancy for a period;
however, those over 35 should switch to IVF or IUI methods without losing time.
Frequently Asked Questions
Should genetic testing be performed in recurrent miscarriages?
Yes. Karyotype or PGT testing should be performed to understand whether there is a genetic problem in the embryo.
Does IVF work after recurrent miscarriages?
Yes. Especially for miscarriages caused by genetic or uterine factors, IVF treatment increases the rate of healthy pregnancy.
Is there treatment for recurrent miscarriages?
Yes. If the underlying cause is correctly identified, pregnancy can be successfully achieved with medical and surgical treatments.