What is FISH PGD?
FISH PGD (Fluorescent in Situ Hybridization) is a genetic diagnostic method based on taking a limited number of cell samples from embryos during in-vitro fertilization (IVF) treatment and performing DNA analysis.
This method is used to investigate whether embryos have aneuploidy (a numerical abnormality of chromosomes) in specific chromosomes.
FertiJin Women’s Health and IVF Center in Istanbul performs FISH PGD analyses according to international genetic laboratory standards.
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How is the FISH PGD method applied?
In FISH (Fluorescent in Situ Hybridization), DNA samples from a limited number of cells taken from the embryo are analyzed using fluorescent markers.
This analysis allows for the detailed evaluation of specific chromosome pairs.
FISH PGD method:
- We analyze DNA samples obtained from embryos under a fluorescent microscope.
- It usually examines the 9 most common chromosomal abnormalities.
- Because it focuses on a limited number of chromosomes, the overall accuracy rate is around 70–80%.
💡 This method is an ideal alternative when NGS (Next Generation Sequencing) or aCGH (Comparative Genomic Hybridization) analyses are not possible.
In which situations are the FISH PGD method preferred?
FISH PGD is generally performed in the following situations:
- In patients for whom next-generation sequencing (NGS) cannot be applied due to technical or financial reasons
- In laboratory conditions where genetic testing infrastructure is limited
- For couples who want to focus on specific chromosomal abnormalities (e.g., 13, 18, 21, X, Y, etc.)
- In those with a history of recurrent miscarriage or failed IVF
This method offers a rapid, economical, and practical genetic screening option, despite its limited chromosome analysis.
Advantages of the FISH PGD Method
| Advantage | Explanation |
| Quick results | Embryo analysis time is shorter compared to other genetic methods. |
| Economic solution | It is more cost-effective than comprehensive testing. |
| It detects fundamental chromosomal abnormalities. | The nine most common chromosomal abnormalities are screened. |
| Alternative analysis possibilities | It can be used in situations where nuclear power plants (NPP) or aCGH (aerosolized carbon dioxide) cannot be built. |
At FertiJin IVF Center, the FISH PGD method is applied with strict laboratory standards and expert genetic counseling support.
Reliability of FISH PGD
FISH PGD offers reliable results in 70–80% of cases. However, because only a limited number of chromosomes are examined, it does not cover all genetic disorders.
Therefore, when necessary, it is supported by more advanced tests such as aCGH or NGS at FertiJin.
💬 “Every step in genetic analysis is important. At FertiJin, the most suitable test plan is tailored to the needs of each couple.”
FISH PGD Prices – Istanbul
The price of a FISH PGD test can vary depending on the number of embryos to be analyzed, the laboratory method used, and whether or not it is used in conjunction with other genetic analyses. FertiJin Women’s Health and IVF Center in Şişli, Istanbul, offers its services with an accessible pricing policy despite its technological infrastructure.
📞 For information and pricing:
💬 WhatsApp: +90 542 386 52 34
👉 Schedule a free initial consultation now
Frequently Asked Questions
Is the FISH PGD test painful?
No. FISH PGD is an analysis performed in a laboratory setting; it is not applied directly to the patient.
Can all genetic diseases be detected with FISH PGD?
No. The method relies on examining a limited number of chromosomes (approximately 9). However, the most common chromosomal abnormalities can be detected.
Should FISH PGD test or NGS be preferred?
NGS is far more comprehensive; however, if this is not possible for technical or financial reasons, FISH PGD is a reliable alternative.