What is NGS (Next Generation Sequencing)?
Next Generation Sequencing (NGS) is one of the most comprehensive chromosome analysis technologies among Preimplantation Genetic Screening (PGT-A) methods. This test, performed before embryo transfer, allows for the detection of potential genetic abnormalities in embryos before the pregnancy process begins.
The NGS method provides detailed screening of all 24 chromosomes
(22 autosomal chromosomes + X and Y sex chromosomes). This allows for the reliable identification of both abnormalities in chromosome number (aneuploidy) and structural changes such as translocations.
FertiJin Women’s Health and IVF Center in Istanbul is one of the few centers that performs the NGS test with a high success rate using advanced genetic laboratory technologies.
👉 Schedule a free initial consultation now.
How does NGS (Next-Generation Sequencing) work?
NGS technology analyzes all chromosomes individually by sequencing the DNA in cell samples taken from the embryo.
This method offers much higher resolution and more reliable results compared to classical genetic tests.
With the NGS test:
- All 24 chromosomes are scanned.
- Chromosome deficiencies or excesses (aneuploidy) are detected.
- Structural abnormalities such as translocations are analyzed,
- Healthy embryos are selected using objective data.
💡 This allows for the genetically most suitable embryo to be identified before embryo transfer, increasing pregnancy success and reducing the risk of miscarriage.
Which patients are suitable for NGS (Neural Tube Delay)?
NGS (Next Generation Sequencing) testing is frequently preferred in the following situations:
- In couples who have previously had unsuccessful in-vitro fertilization (IVF) attempts
- Pregnant women over 38 years of age
- In women with a history of recurrent miscarriages
- In individuals in whom translocation or genetic karyotype alteration is detected
- For couples planning to freeze embryos
- In families who want to rule out sex chromosome disorders
💬 At FertiJin, NGS or other genetic screening methods (PGT, FISH PGD, aCGH, etc.) are planned together according to the specific situation of each couple.
How is the NGS application implemented?
NGS (Neural Genetic Testing) is performed on embryos obtained through in-vitro fertilization (IVF) treatment.
After fertilization, a few cells are taken from the embryos using a biopsy method and sent to a laboratory for genetic analysis.
Today, the most reliable method is considered to be trophectoderm biopsy performed on the 5th or 6th day.
This method allows us to:
- The risk of mosaicism (mixed chromosome structure) is significantly reduced.
- Embryo development is preserved.
- More reliable results are obtained.
After the genetic analysis of the embryos is completed, genetically healthy embryos are selected and transferred to the expectant mother.
Advantages of NGS Testing
| Advantage | Explanation |
| All chromosomes are analyzed. | All 24 chromosomes are scanned in detail. |
| High accuracy rate | NGS method is the most reliable technology in genetic diagnosis. |
| Translocation detection is possible. | Chromosomal structural abnormalities can be identified. |
| It increases pregnancy success. | Selecting healthy embryos increases the success rate. |
| Reduces the risk of miscarriage. | Since genetic problems are detected in advance, the likelihood of miscarriage is reduced. |
💡 At FertiJin IVF Center, NGS procedures are performed according to international genetic laboratory standards, with expert genetic counseling.
NGS Test Prices – Istanbul
The price of an NGS test may vary depending on the number of embryos to be examined, the laboratory method used, and any additional analyses included in the treatment plan. FertiJin Women’s Health and IVF Center
in Şişli, Istanbul, offers its services with an accessible pricing policy and a guarantee of reliable results.
📞 For information and pricing:
💬 WhatsApp: +90 542 386 52 34
👉 Schedule a free initial consultation now
Frequently Asked Questions
Is the NGS test painful?
No. NGS is a genetic analysis performed on embryo cells in a laboratory. The procedure is not directly applied to the prospective mother or father.
What diseases can be detected with the NGS test?
NGS detects chromosomal numerical abnormalities (aneuploidy), translocations, and structural anomalies. It can also determine the sex of the embryo.
Should NGS or FISH PGD be preferred?
NGS is much more comprehensive and has a higher accuracy rate. However, for technical or financial reasons, the FISH PGD method may also be a suitable alternative.